Is darbepoetin safe for cats?
Darbepoetin is effective in treating anemia of kidney disease in humans and may be used in cats.
How quickly does Epogen work in cats?
More erythropoeitin means more red blood cells, which in turn means more oxygen carried. A dose of erythropoietin lasts about a day but its effect is seen approximately five days later when the red cell proliferation it has induced is mature enough for release into the circulation.
What is the difference between epoetin alfa and darbepoetin alfa?
In the United States, epoetin alfa (EPO) is the predominant ESA used by large dialysis chains, whereas the more recently approved longer-acting ESA, darbepoetin alfa (DPO), is mainly used in independent and hospital-based dialysis units.
What is the cost of Aranesp injection?
The cost for Aranesp injectable solution (25 mcg/mL) is around $818 for a supply of 4 milliliters, depending on the pharmacy you visit….Injectable Solution.
What is Epogen used for in cats?
Epogen is a prescription medication used to treat anemia associated with chronic kidney disease and kidney failure. Epogen is safe for use on dogs and cats. Epogen works by stimulating the production of red blood cells, or erythrocytes, which carry oxygen to cells in the body.
How quickly does darbepoetin work?
Darbepoetin alfa injection will help to control your anemia only as long as you continue to use it. It may take 2-6 weeks or longer before you feel the full benefit of darbepoetin alfa injection.
How safe is Aranesp?
Aranesp increases the risk of death, myocardial infarction, stroke, venous thromboembolism, and thrombosis of vascular access and tumor progression or recurrence. Aranesp can also lead to an increase in adverse cardiovascular events, hypertension, seizures, and severe anemia.
Is darbepoetin better than erythropoietin?
Background: Darbepoetin alfa (DA-α) is a long-acting erythropoiesis-stimulating glycoprotein with a three-fold longer half-life than Erythropoietin alfa (EPO).
What is the primary difference between epoetin and darbepoetin?
There are no clinically significant differences in the safety and efficacy of epoetin alfa (Epogen, Procrit) and darbepoetin alfa (Aranesp), the two drugs most commonly used to treat anemia in cancer patients undergoing chemotherapy or radiation treatments, according to a new report by the Agency for Healthcare …
How often should I give my Cat Aranesp?
However, this is by no means inevitable, and only happens to 10% of cats using darbepoetin (Aranesp), the most commonly prescribed ESA. Many vets do not offer ESAs to their clients, saying firstly, they are too expensive, and secondly, it is not fair on the cat having injections three times a week at the vet clinic.
Which is the best erythropoiesis agent for cats?
Darbepoetin alpha (Aranesp®) is now the recommended erythropoiesis-stimulating agent of choice. Although immune reactions may still occur, the incidence is much less common than with Epogen ® use. Generally therapy is considered when the hematocrit is around ≤20% though some clinicians will start earlier.
Are there any ESA’s for cats with CKD?
However, this is by no means inevitable; with the most commonly used ESA, darbepoetin (Aranesp), it only happens to 10% of cats. There are two categories of ESA which have been used in CKD cats: Feline erythropoietin has been developed in small quantities for use in clinical trials. There has also been a study into the feline erythropoietin gene.
When to use ESAs on a cat with anaemia?
A small number of vets seem to rush to use ESAs as soon as a cat is diagnosed with anaemia, even if the cat is barely anaemic. The majority, however, seem to be reluctant to use ESAs because of the risk of an antibody reaction and the cost of the treatment.