Is the drug trilostane safe for dogs with Cushings syndrome?

Is the drug trilostane safe for dogs with Cushings syndrome?

If diagnosing Cushing’s disease was just that easy, there would not be entire books written on the subject. Dr. Feldman, an expert on endocrine disease, noted that trilostane is NOT a benign drug; adverse reaction rates are as high as 25%, death being one of those adverse reactions.

Which is the best medicine for Cushing’s disease?

Cushing’s Syndrome can be treated with a drug called Trilostane. Trilostane, also called Vetoryl, is a newer medication. It has been around quite a few years now, and had gained wide-spread acceptance as a better choice than the older mitotane.

Which is better for Cushing’s disease mitotane or trilostane?

Which one to use is a very complex decision, and involves both the art and the science of veterinary medicine. Which test we use depends on the patient. Trilostane, also called Vetoryl, is a newer medication . It has been around quite a few years now, and had gained wide-spread acceptance as a better choice than the older mitotane.

Is there a cure for Cushing’s disease in dogs?

Cushing’s Disease is a uncommon condition in older dogs, often mistaken for the aging process itself. Yet Cushing’s disease is treatable, and that treatment can result in a longer, more comfortable life for the dog and its owner An endocrine disease is a disease affecting one of the many glands that make hormones.

How is trilostane used to treat Cushings disease?

Trilostane (brand names: Vetoryl®, Desopan®, Modrastane®, or Modrenal®) is used for the treatment of hyperadrenocorticism in dogs (Cushing’s disease) and cats and Alopecia X in dogs. How is trilostane given? Trilostane is given orally (by mouth) in the form of capsules.

How is trilostane used to treat adrenal disease in dogs?

Work done in the late 1990s in Europe demonstrated trilostane’s efficacy in managing canine adrenal disease, and it is presently an approved therapy for dogs with adrenal-and pituitary-dependent hyperadrenocorticism in the United Kingdom and Ireland. Trilostane is administered orally and appears to be rapidly absorbed.

When did trilostane become a first line of treatment?

Historically, Lysodren has been the hallmark of treatment. In 1999, Trilostane, a new treatment option, became FDA approved. Since that time, we have been using it as our usual first line of therapy for pituitary dependent disease.

What kind of test is needed for Cushing’s disease?

When a veterinarian suspects this disease, blood and urine tests are needed to make the diagnosis. Dilute urine and an elevation of the liver enzyme alkaline phosphatase in the blood indicate that testing for CD may be necessary. Cushing’s disease can be verified with an adrenocorticotropic hormone (ACTH) stimulation test.