Is acyclovir toxic to cats?

Is acyclovir toxic to cats?

Acyclovir is an antiviral used for treating herpes outbreaks in humans. However, it is toxic to cats and should be avoided.

Is acyclovir harmful to animals?

Although acyclovir is thought to be low in toxicity, it has caused an obstructive nephropathy from accumulation of crystals in renal tissue. A retrospective review (January 1995 through March 2000) was conducted of acyclovir toxicoses in dogs reported to the ASPCA National Animal Poison Control Center.

Can you overdose on acyclovir?

Accidental, repeated overdoses of oral acyclovir over several days have been associated with gastrointestinal effects (such as nausea and vomiting) and neurological effects (headache and confusion). Intravenous doses administered to humans have been as high as 1,200 mg/m² (28 mg/kg) 3 times daily for up to 2 weeks.

What does lysine do for cats?

For both people and cats, L-lysine is a way to manage and control herpes effectively. This amino acid is present in every cat’s body, but some cats do not have enough of it to ward off infections and illnesses.

What are antivirals for cats?

Famciclovir is an antiviral drug used in veterinary medicine predominantly to treat cats suffering from feline herpes virus and FHV (feline viral rhinotracheitis). Famciclovir itself is not active in either humans or cats; it is metabolized to an active form, penciclovir.

How long does it take acyclovir to start working?

Response and effectiveness. May take up to two hours to reach peak plasma concentrations after oral acyclovir administration. May take up to three days for symptom reduction; however, acyclovir should be taken until the course prescribed is completed. Acyclovir works best when started within 48 hours of symptom onset.

Why is acyclovir less toxic?

Activation of acyclovir to form the nucleoside triphosphate is dependent upon a promiscuous viral thymidine kinase; the low toxicity of acyclovir is due to the activation of acyclovir only in infected cells and the low inhibition of cellular replication (19).

Can I take 2 400mg acyclovir?

Aciclovir 400 mg Tablets are not usually harmful, unless you take too much over several days. Talk to your doctor or pharmacist if you take too much Aciclovir 400 mg Tablets. Take the medicine pack with you. Do not take a double dose to make up for a forgotten dose.

How much acyclovir is in a Zovirax capsule?

Each teaspoonful (5 mL) of ZOVIRAX Suspension contains 200 mg of acyclovir and the inactive ingredients methylparaben 0.1% and propylparaben 0.02% (added as preservatives), carboxymethylcellulose sodium, flavor, glycerin, microcrystalline cellulose, and sorbitol.

What are the inactive ingredients in DailyMed acyclovir tablets?

In addition, each tablet contains the inactive ingredients colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose, povidone and sodium starch glycolate. The 400 mg and 800 mg tablet also contains ferric oxide and FD&C blue lake # 2 Indigo carmine AL, respectively.

What is the brand name for acyclovir tablets?

(acyclovir) Suspension DESCRIPTION ZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpesviruses. ZOVIRAX Capsules, Tablets, and Suspension are formulations for oral administration.

Can you take acyclovir tablets with or without food?

There was no effect of food on the absorption of acyclovir (n = 6); therefore, Acyclovir Tablets, may be administered with or without food. The only known urinary metabolite is 9 – [ (carboxymethoxy)methyl]guanine. The half-life and total body clearance of acyclovir are dependent on renal function.

Is it safe to give acyclovir to cats?

Acyclovir (ACV) has relatively low potency against FHV-1, poor bioavailability, and is potentially toxic when systemically administered to cats. Oral administration of 50 mg/kg acyclovir to cats achieved peak plasma levels of only approximately 40% of target. Common signs of toxicity are referable to bone marrow suppression.

Are there any active ingredients in acyclovir capsules?

Acyclovir is a synthetic nucleoside analogue active against herpes viruses. Acyclovir capsule is a formulation for oral administration. Each capsule of acyclovir contains 200 mg of acyclovir and the inactive ingredients colloidal silicon dioxide, croscarmellose sodium, magnesium stearate and microcrystalline cellulose.

There was no effect of food on the absorption of acyclovir (n = 6); therefore, Acyclovir Tablets, may be administered with or without food. The only known urinary metabolite is 9 – [ (carboxymethoxy)methyl]guanine. The half-life and total body clearance of acyclovir are dependent on renal function.

How are acyclovir tablets used to treat skin cancer?

Treatment with Acyclovir Tablets shortened the time to 50% healing; reduced the maximum number of lesions; reduced the median number of vesicles; decreased the median number of residual lesions on day 28; and decreased the proportion of patients with fever, anorexia, and lethargy by day 2.